![]() ![]() This defines the diffusion coefficient D(x) which serves for calculation of the hydrodynamic particle diameter x. Here, in Part One of this series, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform. The Stokes-Einstein equation establishes the correlation between viscosity and temperature T of the liquid and the size x of the assumed spherical particles and its velocity. This four-part white paper series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. With that said, the challenge that remains with the application of DLS to protein therapeutic formulations is centered around data interpretation. The popularity of DLS within the biopharmaceutical industry is a consequence of the technique’s wide working size and extended sample concentration ranges, as well as its low volume requirements.
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